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Saskia Schlossarek Selected Research

Proteasome Endopeptidase Complex (Proteasome)

1/2022ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes.
6/2014Ubiquitin-proteasome system and hereditary cardiomyopathies.
1/2014Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy.
5/2012Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice.
1/2012Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy.
5/2011The ubiquitin-proteasome system in cardiomyopathies.
1/2010The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy.

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Saskia Schlossarek Research Topics

Disease

19Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
08/2022 - 03/2009
8Hypertrophy
02/2024 - 01/2012
6Heart Diseases (Heart Disease)
02/2024 - 05/2011
5Heart Failure
05/2023 - 08/2007
5Cardiomyopathies (Cardiomyopathy)
01/2020 - 05/2011
4Cardiomegaly (Heart Hypertrophy)
12/2014 - 01/2012
2Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
12/2019 - 01/2019
2Hypertension (High Blood Pressure)
06/2012 - 01/2012
2Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic)
01/2010 - 03/2009
1Atrial Fibrillation
12/2019
1Aortic Valve Stenosis (Aortic Stenosis)
01/2019
1Glycogen Storage Disease Type IIb
10/2017
1Absent corpus callosum cataract immunodeficiency
10/2017
1LEOPARD Syndrome (Syndrome, LEOPARD)
10/2017
1Endocardial Fibroelastosis
01/2016
1Systolic Heart Failure
12/2014
1Body Weight (Weight, Body)
06/2014
1Glomerulonephritis
09/2013
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
08/2013
1Inborn Genetic Diseases (Disease, Hereditary)
07/2013
1Inflammation (Inflammations)
06/2012
1Hyperaldosteronism (Conn Syndrome)
06/2012
1Fibrosis (Cirrhosis)
06/2012

Drug/Important Bio-Agent (IBA)

12Proteins (Proteins, Gene)FDA Link
02/2024 - 03/2009
11Cardiac MyosinsIBA
12/2019 - 08/2007
11Carrier Proteins (Binding Protein)IBA
12/2019 - 08/2007
7Proteasome Endopeptidase Complex (Proteasome)IBA
01/2022 - 01/2010
6UbiquitinIBA
01/2022 - 01/2010
4Messenger RNA (mRNA)IBA
02/2024 - 06/2012
2TubulinIBA
05/2023 - 01/2021
2ActininIBA
08/2022 - 12/2019
2Myosin Heavy Chains (Myosin Heavy Chain)IBA
01/2021 - 01/2012
2myosin-binding protein CIBA
06/2016 - 10/2013
2DesminIBA
10/2015 - 05/2011
2Ubiquitinated ProteinsIBA
06/2014 - 01/2012
2AldosteroneIBA
06/2012 - 01/2012
1CalciumIBA
02/2024
1RNA (Ribonucleic Acid)IBA
10/2021
1Cyclin TIBA
01/2021
1Sirolimus (Rapamycin)FDA Link
10/2017
1TOR Serine-Threonine KinasesIBA
10/2017
1CollagenIBA
01/2016
1ElastinIBA
01/2016
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
10/2015
1Troponin IIBA
06/2015
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
06/2014
1Type 1 Angiotensin ReceptorIBA
06/2014
1IrbesartanFDA LinkGeneric
06/2014
1Proteasome InhibitorsIBA
01/2014
1epoxomicinIBA
01/2014
1NPHS2 proteinIBA
09/2013
1Peptides (Polypeptides)IBA
08/2013
1Antisense OligoribonucleotidesIBA
07/2013
1Brain Natriuretic Peptide (Natrecor)FDA Link
06/2012
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
06/2012
1Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
06/2012
1Galectins (Galectin)IBA
06/2012
1Galectin 3 (LGALS3)IBA
06/2012
1OsteopontinIBA
06/2012
1Bone Morphogenetic Protein 4IBA
06/2012
1Angiotensin IIIBA
06/2012
1Adrenergic Agents (Adrenergic Drugs)IBA
05/2012
1Natriuretic PeptidesIBA
01/2012
1Atrial Natriuretic Factor (ANF)IBA
01/2012
1salicylhydroxamic acid (SHAM)IBA
08/2007

Therapy/Procedure

4Therapeutics
08/2022 - 05/2011
1Caloric Restriction
10/2017
1Aftercare (After-Treatment)
01/2014
1Heart Transplantation (Grafting, Heart)
08/2013